There's finally support for some now quite longstanding OS-level features, such as multi-touch gestures for zooming, and native full-screen mode. This might mean a bit of relearning for Mac users, but the groupings, such as the new Design tab in Word, do make sense. The Ribbon that runs across the top of windows has been slightly reorganised, making it more consistent with Office 2013 on Windows – see the image above for a comparative shot of the Ribbon on Mac, Windows and iPad. While this will look familiar to Windows users, it's a thoroughly Mac aesthetic. Even Office 2011 supported Retina displays, but the entire interface in 2016 has been dramatically modernised – it no longer feels dated on a modern Mac system, and the (optional) coloured toolbars help orientate you in the suite.
Looking over the entire suite, the most obvious difference with this new version of Office, if you've been used to the 2011 edition, is the new interface design.